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Statistical Methods for Dose-Finding Experiments |
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: Chevret |
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: 2006 ³â |
ISBN |
: 9780470861233 |
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: 40,000 ¿ø |
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: 315 ÆäÀÌÁö |
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: 1ÆÇ |
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: Wiley |
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Preface
Introduction
Part I. General Principles and Controversial Issues in Dose-Findings
1. Basic concepts in dose-finding
2. Philosophy and methodology of dose-finding-a regulatory perspective
Part II. Algorithm-Based Approaches
3. Traditional and modified algorithm-based designs for phase I cancer clinical trials
4. Accelerated titration designs
5. Group up-and-down designs in toxicity studies
Part III. Model-Based Approaches
6. The continual reassessment method
7. Using Bayesian decision theory in dose-escalation studies
8. Dose-escalation with overdose control
9. Dose-escalation methods for phase I healthy volunteer studies
Part IV. Future Trends for Past Issues,
10. Defining stopping rules
11. Dose-finding with delayed binary outcomes in cancer trials
12. Dose-finding based on multiple ordinal toxicities in phase I oncology trials
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